Recombinant lactoferrin-derived peptides and their application in enhancing immunity

Abstract

In this study, a recombinant lactoferrin-derived peptide was synthesized, which was obtained by constructing an expression vector, transferring said expression vector into an expression host, and expressing it through said expression host in culture. Its antibacterial activity against Escherichia coli, Salmonella cholerae, Salmonella typhimurium, Salmonella enterica and Staphylococcus aureus, and its antiviral activity against influenza virus, measles virus and mumps virus were confirmed by in vitro antipathogenic and antiviral assays, as well as by in vivo assays in mice, which confirmed its ability to promote the proliferation of mouse splenic lymphocytes and to comprehensively promote the secretion of IL-2, IL-4, IL-13 and IL-3 by mouse lymphocytes, The recombinant peptide Ta was shown to have broad-spectrum antibacterial and antiviral activities, as well as immune boosting effects in mice.