Progress of Transition Metal Complex-Catalyzed Indole Hydrogen Borrowing Method
Abstract
Accompanied by the in-depth study of hydrogen borrowing method, transition metal-catalyzed alkylation of indole C3 with N-H, which avoids the use of alkylating reagents by borrowing hydrogen activation from the substrate, is one of the hotspots of green chemistry research in recent years. The review mainly covers the literature published since 2015, which catalyzes the alkylation of indole C3 with N-H from metal complexes, removes one molecule of water, and completes the hydrogen borrowing. The Borrowed Hydrogen (BH) method is an excellent and widely recognized process without the need for a cumbersome separation process and only water is formed as a by-product.The BH approach is expected to replace the reaction using conventional alkylation reagents and give indoles (the special structure of the drug molecule) to have good reaction pathways in bonding at the C3 to N1 position and in building complex drug molecules.
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DOI: https://doi.org/10.18686/pes.v5i3.1979
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