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Microwave Irradiated and Conventional Synthesis, Antibacterial Activity Evaluation Studies of Indole-Azole-Fluoroquinolone and Indole-Azole Hybrids

Yildiz Uygun Cebeci, Serap Basoglu Ozdemir, Ahmet Demirbas, Neslihan Demirbas, Sengul Alpay Karaoglu

Abstract

Tryptamine was converted to the corresponding 1,2,4-triazole, 1,3,4-oxadiazole, 5-oxo-1,3-thia(oxa)zolidine and 5-(4-chlorophenyl)-1,3-thia(oxa)zole derivatives via several steps. 1,3,4-oxadiazole and 1,2,4-triazoles were then converted to the corresponding Mannich bases containing fluroquinolone core using a one-pot three-components procedure. Conventional and microwave-assisted methods were applied for all syntheses. All the newly synthesized compounds were screened for their antibacterial and most of them were found to have good–moderate antibacterial activity

Keywords

Indole, hybrid compound, multicomponent, microwave, antibacterial activity

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